Soluble P-selectin and correlation with Prothrombin Fragment 1 + 2 in myeloid malignancies in Cipto Mangunkusumo general hospital

Abstract Background Myeloid cells express microparticles that could increase the expression of adhesion molecules including P-selectin. We aimed to evaluate level soluble P-selectin (sP-selectin) and prothrombin fragment 1 + 2 (F1 2), determine correlation sP-selectin with leukocyte count F1 levels in acute myeloid leukemia (AML) chronic (CML) patients. Methods Patients newly diagnosed AML ( n = 25), CML 13), controls 17) were recruited this study. The diagnosis is based on 2001 WHO and/or FAB criteria. Levels determined using enzyme-linked immunosorbent assay kits (Behring ELISA Processor-III® Behring Enzygnost 2). Results was significantly elevated patients compared p 0.001). increased comparison < 0.001 0.043). correlated r 0.437; 0.029) 0.436; Conclusions had an tendency thrombosis. While higher platelet endothelial activation, hypercoagulable state are more pronounced